MTA2-CDHR5 Fusion FISH Probe
The MTA2-CDHR5 Fusion FISH Probe is used to confirm a fusion of the MTA2 and CDHR5 genes. The fusion of the MTA2 and CDHR5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTA2-CDHR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-RERE | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-REOR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-REGO | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-REGR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-REAQ | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-ORRE | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-OROR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-ORGO | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GORE | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GOOR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GOGO | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GOGR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GRRE | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GROR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GRGO | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GRGR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-AQRE | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-AQOR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-AQGO | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-AQGR | 20 (40 μL) | 200 μL |
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| MTA2-CDHR5-20-AQAQ | 20 (40 μL) | 200 μL |
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MTA2 Gene Summary
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Gene Name: Metastasis Associated 1 Family Member 2
Chromosome: CHR11: 62360674 -62369312
Locus: 11q12.3
CDHR5 Gene Summary
This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]
Gene Name: Cadherin Related Family Member 5
Chromosome: CHR11: 616564 -625067
Locus: 11p15.5
Gene Diseases
The MTA2 CDHR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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