MSMB-KLK3 Fusion FISH Probe
The MSMB-KLK3 Fusion FISH Probe is used to confirm a fusion of the MSMB and KLK3 genes. The fusion of the MSMB and KLK3 genes has been associated with Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSMB-KLK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-RERE | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-REOR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-REGO | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-REGR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-REAQ | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-ORRE | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-OROR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-ORGO | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GORE | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GOOR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GOGO | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GOGR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GRRE | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GROR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GRGO | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GRGR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-AQRE | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-AQOR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-AQGO | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-AQGR | 20 (40 μL) | 200 μL |
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| MSMB-KLK3-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK3 Gene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Kallikrein Related Peptidase 3
Chromosome: CHR19: 51358170 -51364020
Locus: 19q13.33
MSMB Gene Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Microseminoprotein Beta
Chromosome: CHR10: 51549552 -51562518
Locus: 10q11.22
Gene Diseases
The MSMB KLK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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