MSLN-CLCN3 Fusion FISH Probe
The MSLN-CLCN3 Fusion FISH Probe is used to confirm a fusion of the MSLN and CLCN3 genes. The fusion of the MSLN and CLCN3 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSLN-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| MSLN-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
MSLN Gene Summary
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Mesothelin
Chromosome: CHR16: 810764 -818865
Locus: 16p13.3
Gene Diseases
The MSLN CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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