MSH2-SPTLC1 Fusion FISH Probe
The MSH2-SPTLC1 Fusion FISH Probe is used to confirm a fusion of the MSH2 and SPTLC1 genes. The fusion of the MSH2 and SPTLC1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSH2-SPTLC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-RERE | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-REOR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-REGO | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-REGR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-REAQ | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-ORRE | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-OROR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-ORGO | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GORE | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GOOR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GOGO | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GOGR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GRRE | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GROR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GRGO | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GRGR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-AQRE | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-AQOR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-AQGO | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-AQGR | 20 (40 μL) | 200 μL |
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| MSH2-SPTLC1-20-AQAQ | 20 (40 μL) | 200 μL |
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MSH2 Gene Summary
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: MutS Homolog 2
Chromosome: CHR2: 47630262 -47710360
Locus: 2p21-p16.3
SPTLC1 Gene Summary
This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]
Gene Name: Serine Palmitoyltransferase Long Chain Base Subunit 1
Chromosome: CHR9: 94793426 -94877690
Locus: 9q22.31
Gene Diseases
The MSH2 SPTLC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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