MSH2-EPCAM Fusion FISH Probe
The MSH2-EPCAM Fusion FISH Probe is used to confirm a fusion of the MSH2 and EPCAM genes. The fusion of the MSH2 and EPCAM genes has been associated with Stomach Adenocarcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSH2-EPCAM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-RERE | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-REOR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-REGO | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-REGR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-REAQ | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-ORRE | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-OROR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-ORGO | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GORE | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GOOR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GOGO | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GOGR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GRRE | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GROR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GRGO | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GRGR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-AQRE | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-AQOR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-AQGO | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-AQGR | 20 (40 μL) | 200 μL |
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| MSH2-EPCAM-20-AQAQ | 20 (40 μL) | 200 μL |
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EPCAM Gene Summary
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Gene Name: Epithelial Cell Adhesion Molecule
Chromosome: CHR2: 47596286 -47614167
Locus: 2p21
MSH2 Gene Summary
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: MutS Homolog 2
Chromosome: CHR2: 47630262 -47710360
Locus: 2p21-p16.3
Gene Diseases
The MSH2 EPCAM Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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