MRPS7-GGA3 Fusion FISH Probe
The MRPS7-GGA3 Fusion FISH Probe is used to confirm a fusion of the MRPS7 and GGA3 genes. The fusion of the MRPS7 and GGA3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPS7-GGA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-RERE | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-REOR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-REGO | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-REGR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-OROR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GORE | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GROR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPS7-GGA3-20-AQAQ | 20 (40 μL) | 200 μL |
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GGA3 Gene Summary
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
Gene Name: Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3
Chromosome: CHR17: 73232693 -73258444
Locus: 17q25.1
MRPS7 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S7
Chromosome: CHR17: 73257748 -73262457
Locus: 17q25.1
Gene Diseases
The MRPS7 GGA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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