MRPS5-NEB Fusion FISH Probe
The MRPS5-NEB Fusion FISH Probe is used to confirm a fusion of the MRPS5 and NEB genes. The fusion of the MRPS5 and NEB genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPS5-NEB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-RERE | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-REOR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-REGO | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-REGR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-OROR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GORE | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GROR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPS5-NEB-20-AQAQ | 20 (40 μL) | 200 μL |
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NEB Gene Summary
This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009]
Gene Name: Nebulin
Chromosome: CHR2: 152341852 -152591001
Locus: 2q23.3
MRPS5 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S5
Chromosome: CHR2: 95752951 -95787754
Locus: 2q11.1
Gene Diseases
The MRPS5 NEB Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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