MRPS27-HIST1H2BN Fusion FISH Probe
The MRPS27-HIST1H2BN Fusion FISH Probe is used to confirm a fusion of the MRPS27 and HIST1H2BN genes. The fusion of the MRPS27 and HIST1H2BN genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPS27-HIST1H2BN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-RERE | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-REOR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-REGO | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-REGR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-OROR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GORE | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GROR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPS27-HIST1H2BN-20-AQAQ | 20 (40 μL) | 200 μL |
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HIST1H2BN Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 1 H2B Family Member N
Chromosome: CHR6: 27806439 -27806888
Locus: 6p22.1
MRPS27 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]
Gene Name: Mitochondrial Ribosomal Protein S27
Chromosome: CHR5: 71515235 -71616084
Locus: 5q13.2
Gene Diseases
The MRPS27 HIST1H2BN Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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