MRPL49-ARL2 Fusion FISH Probe
The MRPL49-ARL2 Fusion FISH Probe is used to confirm a fusion of the MRPL49 and ARL2 genes. The fusion of the MRPL49 and ARL2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPL49-ARL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-RERE | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-REOR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-REGO | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-REGR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-OROR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GORE | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GROR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPL49-ARL2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARL2 Gene Summary
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Like GTPase 2
Chromosome: CHR11: 64781584 -64789657
Locus: 11q13.1
MRPL49 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]
Gene Name: Mitochondrial Ribosomal Protein L49
Chromosome: CHR11: 64889654 -64894841
Locus: 11q13.1
Gene Diseases
The MRPL49 ARL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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