MRPL48-NARS2 Fusion FISH Probe
The MRPL48-NARS2 Fusion FISH Probe is used to confirm a fusion of the MRPL48 and NARS2 genes. The fusion of the MRPL48 and NARS2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPL48-NARS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-RERE | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-REOR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-REGO | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-REGR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-OROR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GORE | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GROR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPL48-NARS2-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPL48 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Mitochondrial Ribosomal Protein L48
Chromosome: CHR11: 73498916 -73575656
Locus: 11q13.4
NARS2 Gene Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]
Gene Name: Asparaginyl-tRNA Synthetase 2, Mitochondrial
Chromosome: CHR11: 78147006 -78285909
Locus: 11q14.1
Gene Diseases
The MRPL48 NARS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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