MRPL42-ZMIZ1 Fusion FISH Probe
The MRPL42-ZMIZ1 Fusion FISH Probe is used to confirm a fusion of the MRPL42 and ZMIZ1 genes. The fusion of the MRPL42 and ZMIZ1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPL42-ZMIZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-RERE | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-REOR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-REGO | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-REGR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-OROR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GORE | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GROR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPL42-ZMIZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPL42 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]
Gene Name: Mitochondrial Ribosomal Protein L42
Chromosome: CHR12: 93861265 -93897548
Locus: 12q22
ZMIZ1 Gene Summary
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Gene Name: Zinc Finger MIZ-type Containing 1
Chromosome: CHR10: 80828791 -81076285
Locus: 10q22.3
Gene Diseases
The MRPL42 ZMIZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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