MRPL37-MASP2 Fusion FISH Probe
The MRPL37-MASP2 Fusion FISH Probe is used to confirm a fusion of the MRPL37 and MASP2 genes. The fusion of the MRPL37 and MASP2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPL37-MASP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-RERE | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-REOR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-REGO | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-REGR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-OROR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GORE | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GROR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPL37-MASP2-20-AQAQ | 20 (40 μL) | 200 μL |
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MASP2 Gene Summary
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Mannan Binding Lectin Serine Peptidase 2
Chromosome: CHR1: 11086579 -11107296
Locus: 1p36.22
MRPL37 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L37
Chromosome: CHR1: 54665839 -54684056
Locus: 1p32.3
Gene Diseases
The MRPL37 MASP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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