MRPL33-RBKS Fusion FISH Probe
The MRPL33-RBKS Fusion FISH Probe is used to confirm a fusion of the MRPL33 and RBKS genes. The fusion of the MRPL33 and RBKS genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPL33-RBKS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-RERE | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-REOR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-REGO | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-REGR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-OROR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GORE | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GROR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPL33-RBKS-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPL33 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L33
Chromosome: CHR2: 27994583 -28002608
Locus: 2p23.2
RBKS Gene Summary
This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Name: Ribokinase
Chromosome: CHR2: 28004265 -28113223
Locus: 2p23.2
Gene Diseases
The MRPL33 RBKS Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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