MRPL21-LRP5 Fusion FISH Probe
The MRPL21-LRP5 Fusion FISH Probe is used to confirm a fusion of the MRPL21 and LRP5 genes. The fusion of the MRPL21 and LRP5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MRPL21-LRP5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MRPL21-LRP5-20-AQAQ | 20 (40 μL) | 200 μL |
|
LRP5 Gene Summary
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: LDL Receptor Related Protein 5
Chromosome: CHR11: 68080107 -68216743
Locus: 11q13.2
MRPL21 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L21
Chromosome: CHR11: 68658745 -68671303
Locus: 11q13.3
Gene Diseases
The MRPL21 LRP5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|