MPRIP-OAZ2 Fusion FISH Probe
The MPRIP-OAZ2 Fusion FISH Probe is used to confirm a fusion of the MPRIP and OAZ2 genes. The fusion of the MPRIP and OAZ2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MPRIP-OAZ2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-RERE | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-REOR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-REGO | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-REGR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-REAQ | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-ORRE | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-OROR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-ORGO | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GORE | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GOOR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GOGO | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GOGR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GRRE | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GROR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GRGO | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GRGR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-AQRE | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-AQOR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-AQGO | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-AQGR | 20 (40 μL) | 200 μL |
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| MPRIP-OAZ2-20-AQAQ | 20 (40 μL) | 200 μL |
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OAZ2 Gene Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Gene Name: Ornithine Decarboxylase Antizyme 2
Chromosome: CHR15: 64979772 -64995462
Locus: 15q22.31
MPRIP Gene Summary
The Myosin Phosphatase Rho Interacting Protein (MPRIP) gene is located on chr17 :16946073-17095962 at 17p11.2.
Gene Name: Myosin Phosphatase Rho Interacting Protein
Chromosome: CHR17: 16946073 -17095962
Locus: 17p11.2
Gene Diseases
The MPRIP OAZ2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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