MPP2-PPY Fusion FISH Probe
The MPP2-PPY Fusion FISH Probe is used to confirm a fusion of the MPP2 and PPY genes. The fusion of the MPP2 and PPY genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MPP2-PPY-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-RERE | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-REOR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-REGO | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-REGR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-REAQ | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-ORRE | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-OROR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-ORGO | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-ORAQ | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GORE | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GOOR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GOGO | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GOGR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GOAQ | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GRRE | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GROR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GRGO | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GRGR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-GRAQ | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-AQRE | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-AQOR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-AQGO | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-AQGR | 20 (40 μL) | 200 μL |
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| MPP2-PPY-20-AQAQ | 20 (40 μL) | 200 μL |
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MPP2 Gene Summary
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Gene Name: Membrane Palmitoylated Protein 2
Chromosome: CHR17: 41952726 -41985113
Locus: 17q21.31
PPY Gene Summary
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Pancreatic Polypeptide
Chromosome: CHR17: 42018171 -42019833
Locus: 17q21.31
Gene Diseases
The MPP2 PPY Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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