MPO-FAR1 Fusion FISH Probe
The MPO-FAR1 Fusion FISH Probe is used to confirm a fusion of the MPO and FAR1 genes. The fusion of the MPO and FAR1 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MPO-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| MPO-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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MPO Gene Summary
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Gene Name: Myeloperoxidase
Chromosome: CHR17: 56347216 -56358296
Locus: 17q22
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The MPO FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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