MORC2-PATZ1 Fusion FISH Probe
The MORC2-PATZ1 Fusion FISH Probe is used to confirm a fusion of the MORC2 and PATZ1 genes. The fusion of the MORC2 and PATZ1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MORC2-PATZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-RERE | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-REOR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-REGO | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-REGR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-OROR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GORE | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GROR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| MORC2-PATZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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MORC2 Gene Summary
This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Gene Name: MORC Family CW-type Zinc Finger 2
Chromosome: CHR22: 31322599 -31364187
Locus: 22q12.2
PATZ1 Gene Summary
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: POZ/BTB And AT Hook Containing Zinc Finger 1
Chromosome: CHR22: 31721789 -31742249
Locus: 22q12.2
Gene Diseases
The MORC2 PATZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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