MOCS1-LEMD3 Fusion FISH Probe
The MOCS1-LEMD3 Fusion FISH Probe is used to confirm a fusion of the MOCS1 and LEMD3 genes. The fusion of the MOCS1 and LEMD3 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MOCS1-LEMD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-RERE | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-REOR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-REGO | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-REGR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-REAQ | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-ORRE | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-OROR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-ORGO | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GORE | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GOOR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GOGO | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GOGR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GRRE | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GROR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GRGO | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GRGR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-AQRE | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-AQOR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-AQGO | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-AQGR | 20 (40 μL) | 200 μL |
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| MOCS1-LEMD3-20-AQAQ | 20 (40 μL) | 200 μL |
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MOCS1 Gene Summary
Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Nov 2017]
Gene Name: Molybdenum Cofactor Synthesis 1
Chromosome: CHR6: 39872033 -39902290
Locus: 6p21.2
LEMD3 Gene Summary
This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
Gene Name: LEM Domain Containing 3
Chromosome: CHR12: 65563350 -65642141
Locus: 12q14.3
Gene Diseases
The MOCS1 LEMD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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