MMP15-CDH5 Fusion FISH Probe
The MMP15-CDH5 Fusion FISH Probe is used to confirm a fusion of the MMP15 and CDH5 genes. The fusion of the MMP15 and CDH5 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MMP15-CDH5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-RERE | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-REOR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-REGO | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-REGR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-REAQ | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-ORRE | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-OROR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-ORGO | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GORE | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GOOR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GOGO | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GOGR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GRRE | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GROR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GRGO | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GRGR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-AQRE | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-AQOR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-AQGO | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-AQGR | 20 (40 μL) | 200 μL |
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| MMP15-CDH5-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH5 Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 5
Chromosome: CHR16: 66400524 -66438689
Locus: 16q21
MMP15 Gene Summary
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]
Gene Name: Matrix Metallopeptidase 15
Chromosome: CHR16: 58059281 -58080804
Locus: 16q21
Gene Diseases
The MMP15 CDH5 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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