MMP14-RBM23 Fusion FISH Probe
The MMP14-RBM23 Fusion FISH Probe is used to confirm a fusion of the MMP14 and RBM23 genes. The fusion of the MMP14 and RBM23 genes has been associated with Kidney Chromophobe. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MMP14-RBM23-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-RERE | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-REOR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-REGO | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-REGR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-REAQ | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-ORRE | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-OROR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-ORGO | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-ORAQ | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GORE | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GOOR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GOGO | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GOGR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GOAQ | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GRRE | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GROR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GRGO | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GRGR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-GRAQ | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-AQRE | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-AQOR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-AQGO | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-AQGR | 20 (40 μL) | 200 μL |
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| MMP14-RBM23-20-AQAQ | 20 (40 μL) | 200 μL |
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MMP14 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Gene Name: Matrix Metallopeptidase 14
Chromosome: CHR14: 23305792 -23316803
Locus: 14q11.2
RBM23 Gene Summary
This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: RNA Binding Motif Protein 23
Chromosome: CHR14: 23369853 -23388396
Locus: 14q11.2
Gene Diseases
The MMP14 RBM23 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Chromophobe |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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