MMP14-CCT5 Fusion FISH Probe
The MMP14-CCT5 Fusion FISH Probe is used to confirm a fusion of the MMP14 and CCT5 genes. The fusion of the MMP14 and CCT5 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MMP14-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| MMP14-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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MMP14 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Gene Name: Matrix Metallopeptidase 14
Chromosome: CHR14: 23305792 -23316803
Locus: 14q11.2
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The MMP14 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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