MMP13-SUPT16H Fusion FISH Probe
The MMP13-SUPT16H Fusion FISH Probe is used to confirm a fusion of the MMP13 and SUPT16H genes. The fusion of the MMP13 and SUPT16H genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MMP13-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| MMP13-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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MMP13 Gene Summary
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Gene Name: Matrix Metallopeptidase 13
Chromosome: CHR11: 102813720 -102826463
Locus: 11q22.2
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The MMP13 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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