MLLT6-PPP1R12A Fusion FISH Probe
The MLLT6-PPP1R12A Fusion FISH Probe is used to confirm a fusion of the MLLT6 and PPP1R12A genes. The fusion of the MLLT6 and PPP1R12A genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MLLT6-PPP1R12A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-RERE | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-REOR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-REGO | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-REGR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-REAQ | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-ORRE | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-OROR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-ORGO | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GORE | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GOOR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GOGO | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GOGR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GRRE | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GROR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GRGO | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GRGR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-AQRE | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-AQOR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-AQGO | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-AQGR | 20 (40 μL) | 200 μL |
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| MLLT6-PPP1R12A-20-AQAQ | 20 (40 μL) | 200 μL |
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MLLT6 Gene Summary
The MLLT6, PHD Finger Containing (MLLT6) gene is located on chr17 :36861872-36886056 at 17q12.
Gene Name: MLLT6, PHD Finger Containing
Chromosome: CHR17: 36861872 -36886056
Locus: 17q12
PPP1R12A Gene Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12A
Chromosome: CHR12: 80167342 -80329235
Locus: 12q21.2-q21.31
Gene Diseases
The MLLT6 PPP1R12A Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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