MLLT10-ASCC1 Fusion FISH Probe
The MLLT10-ASCC1 Fusion FISH Probe is used to confirm a fusion of the MLLT10 and ASCC1 genes. The fusion of the MLLT10 and ASCC1 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MLLT10-ASCC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-RERE | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-REOR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-REGO | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-REGR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-REAQ | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-ORRE | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-OROR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-ORGO | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GORE | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GOOR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GOGO | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GOGR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GRRE | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GROR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GRGO | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GRGR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-AQRE | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-AQOR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-AQGO | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-AQGR | 20 (40 μL) | 200 μL |
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| MLLT10-ASCC1-20-AQAQ | 20 (40 μL) | 200 μL |
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MLLT10 Gene Summary
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Name: MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
Chromosome: CHR10: 21823100 -22032559
Locus: 10p12.31
ASCC1 Gene Summary
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Activating Signal Cointegrator 1 Complex Subunit 1
Chromosome: CHR10: 73856273 -73976183
Locus: 10q22.1
Gene Diseases
The MLLT10 ASCC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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