MLL5-MAP2K3 Fusion FISH Probe
The MLL5-MAP2K3 Fusion FISH Probe is used to confirm a fusion of the MLL5 and MAP2K3 genes. The fusion of the MLL5 and MAP2K3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MLL5-MAP2K3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-RERE | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-REOR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-REGO | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-REGR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-REAQ | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-ORRE | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-OROR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-ORGO | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GORE | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GOOR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GOGO | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GOGR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GRRE | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GROR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GRGO | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GRGR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-AQRE | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-AQOR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-AQGO | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-AQGR | 20 (40 μL) | 200 μL |
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| MLL5-MAP2K3-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP2K3 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase 3
Chromosome: CHR17: 21187967 -21218551
Locus: 17p11.2
Gene Diseases
The MLL5 MAP2K3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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