MLL3-IRF5 Fusion FISH Probe
The MLL3-IRF5 Fusion FISH Probe is used to confirm a fusion of the MLL3 and IRF5 genes. The fusion of the MLL3 and IRF5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MLL3-IRF5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-RERE | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-REOR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-REGO | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-REGR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-REAQ | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-ORRE | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-OROR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-ORGO | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GORE | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GOOR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GOGO | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GOGR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GRRE | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GROR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GRGO | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GRGR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-AQRE | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-AQOR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-AQGO | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-AQGR | 20 (40 μL) | 200 μL |
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| MLL3-IRF5-20-AQAQ | 20 (40 μL) | 200 μL |
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IRF5 Gene Summary
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]
Gene Name: Interferon Regulatory Factor 5
Chromosome: CHR7: 128577993 -128590088
Locus: 7q32.1
Gene Diseases
The MLL3 IRF5 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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