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MLL-MLLT10 Fusion FISH Probe

The MLL-MLLT10 Fusion FISH Probe is used to confirm a fusion of the MLL and MLLT10 genes. The fusion of the MLL and MLLT10 genes has been associated with Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, and Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MLL-MLLT10-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MLL-MLLT10-20-RERE 20 (40 μL) 200 μL
MLL-MLLT10-20-REOR 20 (40 μL) 200 μL
MLL-MLLT10-20-REGO 20 (40 μL) 200 μL
MLL-MLLT10-20-REGR 20 (40 μL) 200 μL
MLL-MLLT10-20-REAQ 20 (40 μL) 200 μL
MLL-MLLT10-20-ORRE 20 (40 μL) 200 μL
MLL-MLLT10-20-OROR 20 (40 μL) 200 μL
MLL-MLLT10-20-ORGO 20 (40 μL) 200 μL
MLL-MLLT10-20-ORAQ 20 (40 μL) 200 μL
MLL-MLLT10-20-GORE 20 (40 μL) 200 μL
MLL-MLLT10-20-GOOR 20 (40 μL) 200 μL
MLL-MLLT10-20-GOGO 20 (40 μL) 200 μL
MLL-MLLT10-20-GOGR 20 (40 μL) 200 μL
MLL-MLLT10-20-GOAQ 20 (40 μL) 200 μL
MLL-MLLT10-20-GRRE 20 (40 μL) 200 μL
MLL-MLLT10-20-GROR 20 (40 μL) 200 μL
MLL-MLLT10-20-GRGO 20 (40 μL) 200 μL
MLL-MLLT10-20-GRGR 20 (40 μL) 200 μL
MLL-MLLT10-20-GRAQ 20 (40 μL) 200 μL
MLL-MLLT10-20-AQRE 20 (40 μL) 200 μL
MLL-MLLT10-20-AQOR 20 (40 μL) 200 μL
MLL-MLLT10-20-AQGO 20 (40 μL) 200 μL
MLL-MLLT10-20-AQGR 20 (40 μL) 200 μL
MLL-MLLT10-20-AQAQ 20 (40 μL) 200 μL

MLLT10 Gene Summary

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Name: MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor

Chromosome: CHR10: 21823100 -22032559

Locus: 10p12.31

Gene Diseases

The MLL MLLT10 Fusion has been associated with the following diseases:

Disease Name
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene

This study investigated a case of myeloid sarcoma (MS), a rare tumor often misdiagnosed as malignant lymphoma, that developed into acute myeloid leukemia (AML). Along with pathologic, morphologic, and immunophenotypic characterization, FISH was used to screen for cytogenetic abnormalities. Our MLLT10 helped detect a rare PICALM-MLLT10 fusion in the patient, an abnormality consistent with disease progression to AML.