MKRN2-PPARG Fusion FISH Probe
The MKRN2-PPARG Fusion FISH Probe is used to confirm a fusion of the MKRN2 and PPARG genes. The fusion of the MKRN2 and PPARG genes has been associated with Bladder Urothelial Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKRN2-PPARG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-RERE | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-REOR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-REGO | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-REGR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-REAQ | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-ORRE | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-OROR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-ORGO | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GORE | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GOOR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GOGO | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GOGR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GRRE | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GROR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GRGO | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GRGR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-AQRE | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-AQOR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-AQGO | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-AQGR | 20 (40 μL) | 200 μL |
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| MKRN2-PPARG-20-AQAQ | 20 (40 μL) | 200 μL |
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PPARG Gene Summary
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Peroxisome Proliferator Activated Receptor Gamma
Chromosome: CHR3: 12329348 -12475855
Locus: 3p25.2
MKRN2 Gene Summary
This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Name: Makorin Ring Finger Protein 2
Chromosome: CHR3: 12598593 -12625210
Locus: 3p25.2
Gene Diseases
The MKRN2 PPARG Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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