MKRN1-NLGN1 Fusion FISH Probe
The MKRN1-NLGN1 Fusion FISH Probe is used to confirm a fusion of the MKRN1 and NLGN1 genes. The fusion of the MKRN1 and NLGN1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKRN1-NLGN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-RERE | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-REOR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-REGO | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-REGR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-REAQ | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-ORRE | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-OROR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-ORGO | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GORE | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GOOR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GOGO | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GOGR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GRRE | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GROR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GRGO | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GRGR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-AQRE | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-AQOR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-AQGO | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-AQGR | 20 (40 μL) | 200 μL |
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| MKRN1-NLGN1-20-AQAQ | 20 (40 μL) | 200 μL |
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NLGN1 Gene Summary
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Gene Name: Neuroligin 1
Chromosome: CHR3: 173116243 -174001116
Locus: 3q26.31
MKRN1 Gene Summary
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Makorin Ring Finger Protein 1
Chromosome: CHR7: 140152839 -140179369
Locus: 7q34
Gene Diseases
The MKRN1 NLGN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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