MKRN1-MRPS33 Fusion FISH Probe
The MKRN1-MRPS33 Fusion FISH Probe is used to confirm a fusion of the MKRN1 and MRPS33 genes. The fusion of the MKRN1 and MRPS33 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKRN1-MRPS33-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-RERE | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-REOR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-REGO | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-REGR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-REAQ | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-ORRE | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-OROR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-ORGO | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GORE | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GOOR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GOGO | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GOGR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GRRE | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GROR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GRGO | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GRGR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-AQRE | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-AQOR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-AQGO | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-AQGR | 20 (40 μL) | 200 μL |
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| MKRN1-MRPS33-20-AQAQ | 20 (40 μL) | 200 μL |
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MKRN1 Gene Summary
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Makorin Ring Finger Protein 1
Chromosome: CHR7: 140152839 -140179369
Locus: 7q34
MRPS33 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S33
Chromosome: CHR7: 140705960 -140714781
Locus: 7q34
Gene Diseases
The MKRN1 MRPS33 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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