MKRN1-DENND2A Fusion FISH Probe
The MKRN1-DENND2A Fusion FISH Probe is used to confirm a fusion of the MKRN1 and DENND2A genes. The fusion of the MKRN1 and DENND2A genes has been associated with Bladder Urothelial Carcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKRN1-DENND2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-RERE | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-REOR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-REGO | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-REGR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-REAQ | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-ORRE | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-OROR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-ORGO | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GORE | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GOOR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GOGO | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GOGR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GRRE | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GROR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GRGO | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GRGR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-AQRE | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-AQOR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-AQGO | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-AQGR | 20 (40 μL) | 200 μL |
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| MKRN1-DENND2A-20-AQAQ | 20 (40 μL) | 200 μL |
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MKRN1 Gene Summary
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Makorin Ring Finger Protein 1
Chromosome: CHR7: 140152839 -140179369
Locus: 7q34
DENND2A Gene Summary
The DENN Domain Containing 2A (DENND2A) gene is located on chr7 :140218219-140302342 at 7q34.
Gene Name: DENN Domain Containing 2A
Chromosome: CHR7: 140218219 -140302342
Locus: 7q34
Gene Diseases
The MKRN1 DENND2A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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