MKRN1-BRAF Fusion FISH Probe
The MKRN1-BRAF Fusion FISH Probe is used to confirm a fusion of the MKRN1 and BRAF genes. The fusion of the MKRN1 and BRAF genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKRN1-BRAF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-RERE | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-REOR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-REGO | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-REGR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-REAQ | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-ORRE | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-OROR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-ORGO | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GORE | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GOOR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GOGO | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GOGR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GRRE | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GROR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GRGO | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GRGR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-AQRE | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-AQOR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-AQGO | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-AQGR | 20 (40 μL) | 200 μL |
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| MKRN1-BRAF-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
MKRN1 Gene Summary
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Makorin Ring Finger Protein 1
Chromosome: CHR7: 140152839 -140179369
Locus: 7q34
Gene Diseases
The MKRN1 BRAF Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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