MKNK2-RNF126 Fusion FISH Probe
The MKNK2-RNF126 Fusion FISH Probe is used to confirm a fusion of the MKNK2 and RNF126 genes. The fusion of the MKNK2 and RNF126 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKNK2-RNF126-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-RERE | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-REOR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-REGO | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-REGR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-REAQ | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-ORRE | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-OROR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-ORGO | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GORE | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GOOR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GOGO | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GOGR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GRRE | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GROR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GRGO | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GRGR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-AQRE | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-AQOR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-AQGO | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-AQGR | 20 (40 μL) | 200 μL |
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| MKNK2-RNF126-20-AQAQ | 20 (40 μL) | 200 μL |
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MKNK2 Gene Summary
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Gene Name: MAP Kinase Interacting Serine/threonine Kinase 2
Chromosome: CHR19: 2037469 -2051243
Locus: 19p13.3
RNF126 Gene Summary
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 126
Chromosome: CHR19: 647525 -663233
Locus: 19p13.3
Gene Diseases
The MKNK2 RNF126 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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