MKNK2-FAM151A Fusion FISH Probe
The MKNK2-FAM151A Fusion FISH Probe is used to confirm a fusion of the MKNK2 and FAM151A genes. The fusion of the MKNK2 and FAM151A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKNK2-FAM151A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-RERE | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-REOR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-REGO | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-REGR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-REAQ | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-ORRE | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-OROR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-ORGO | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GORE | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GOOR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GOGO | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GOGR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GRRE | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GROR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GRGO | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GRGR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-AQRE | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-AQOR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-AQGO | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-AQGR | 20 (40 μL) | 200 μL |
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| MKNK2-FAM151A-20-AQAQ | 20 (40 μL) | 200 μL |
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MKNK2 Gene Summary
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Gene Name: MAP Kinase Interacting Serine/threonine Kinase 2
Chromosome: CHR19: 2037469 -2051243
Locus: 19p13.3
FAM151A Gene Summary
The Family With Sequence Similarity 151 Member A (FAM151A) gene is located on chr1 :55074849-55089200 at .
Gene Name: Family With Sequence Similarity 151 Member A
Chromosome: CHR1: 55074849 -55089200
Gene Diseases
The MKNK2 FAM151A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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