MKLN1-NRF1 Fusion FISH Probe
The MKLN1-NRF1 Fusion FISH Probe is used to confirm a fusion of the MKLN1 and NRF1 genes. The fusion of the MKLN1 and NRF1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKLN1-NRF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-RERE | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-REOR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-REGO | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-REGR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-OROR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GORE | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GROR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| MKLN1-NRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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MKLN1 Gene Summary
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Gene Name: Muskelin 1
Chromosome: CHR7: 130794854 -131181398
Locus: 7q32.3
NRF1 Gene Summary
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Gene Name: Nuclear Respiratory Factor 1
Chromosome: CHR7: 129251554 -129396922
Locus: 7q32.2
Gene Diseases
The MKLN1 NRF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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