MKLN1-GRM8 Fusion FISH Probe
The MKLN1-GRM8 Fusion FISH Probe is used to confirm a fusion of the MKLN1 and GRM8 genes. The fusion of the MKLN1 and GRM8 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKLN1-GRM8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-RERE | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-REOR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-REGO | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-REGR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-REAQ | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-ORRE | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-OROR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-ORGO | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GORE | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GOOR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GOGO | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GOGR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GRRE | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GROR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GRGO | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GRGR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-AQRE | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-AQOR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-AQGO | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-AQGR | 20 (40 μL) | 200 μL |
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| MKLN1-GRM8-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM8 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Metabotropic Receptor 8
Chromosome: CHR7: 126078651 -126892428
Locus: 7q31.33
MKLN1 Gene Summary
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Gene Name: Muskelin 1
Chromosome: CHR7: 130794854 -131181398
Locus: 7q32.3
Gene Diseases
The MKLN1 GRM8 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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