MKL2-FRMD4A Fusion FISH Probe
The MKL2-FRMD4A Fusion FISH Probe is used to confirm a fusion of the MKL2 and FRMD4A genes. The fusion of the MKL2 and FRMD4A genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL2-FRMD4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-RERE | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-REOR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-REGO | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-REGR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-OROR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GORE | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GROR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL2-FRMD4A-20-AQAQ | 20 (40 μL) | 200 μL |
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FRMD4A Gene Summary
This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: FERM Domain Containing 4A
Chromosome: CHR10: 13685705 -14372866
Locus: 10p13
MKL2 Gene Summary
The MKL1/myocardin Like 2 (MKL2) gene is located on chr16 :14165195-14360630 at 16p13.12.
Gene Name: MKL1/myocardin Like 2
Chromosome: CHR16: 14165195 -14360630
Locus: 16p13.12
Gene Diseases
The MKL2 FRMD4A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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