MKL2-CACNA1H Fusion FISH Probe
The MKL2-CACNA1H Fusion FISH Probe is used to confirm a fusion of the MKL2 and CACNA1H genes. The fusion of the MKL2 and CACNA1H genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL2-CACNA1H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-RERE | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-REOR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-REGO | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-REGR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-OROR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GORE | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GROR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL2-CACNA1H-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1H Gene Summary
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 H
Chromosome: CHR16: 1203240 -1271772
Locus: 16p13.3
MKL2 Gene Summary
The MKL1/myocardin Like 2 (MKL2) gene is located on chr16 :14165195-14360630 at 16p13.12.
Gene Name: MKL1/myocardin Like 2
Chromosome: CHR16: 14165195 -14360630
Locus: 16p13.12
Gene Diseases
The MKL2 CACNA1H Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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