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MKL1-WFIKKN2 Fusion FISH Probe

The MKL1-WFIKKN2 Fusion FISH Probe is used to confirm a fusion of the MKL1 and WFIKKN2 genes. The fusion of the MKL1 and WFIKKN2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MKL1-WFIKKN2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-RERE 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-REOR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-REGO 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-REGR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-REAQ 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-ORRE 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-OROR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-ORGO 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-ORAQ 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GORE 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GOOR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GOGO 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GOGR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GOAQ 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GRRE 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GROR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GRGO 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GRGR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-GRAQ 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-AQRE 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-AQOR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-AQGO 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-AQGR 20 (40 μL) 200 μL
MKL1-WFIKKN2-20-AQAQ 20 (40 μL) 200 μL

MKL1 Gene Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Name: Megakaryoblastic Leukemia (translocation) 1

Chromosome: CHR22: 40806291 -41032690

Locus: 22q13.1-q13.2

WFIKKN2 Gene Summary

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

Gene Name: WAP, Follistatin/kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2

Chromosome: CHR17: 48912604 -48919709

Locus: 17q21.33

Gene Diseases

The MKL1 WFIKKN2 Fusion has been associated with the following diseases:

Disease Name
Liver Hepatocellular Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.