MKL1-WFIKKN2 Fusion FISH Probe
The MKL1-WFIKKN2 Fusion FISH Probe is used to confirm a fusion of the MKL1 and WFIKKN2 genes. The fusion of the MKL1 and WFIKKN2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL1-WFIKKN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-RERE | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-REOR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-REGO | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-REGR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-OROR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GORE | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GROR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL1-WFIKKN2-20-AQAQ | 20 (40 μL) | 200 μL |
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MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
WFIKKN2 Gene Summary
The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]
Gene Name: WAP, Follistatin/kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2
Chromosome: CHR17: 48912604 -48919709
Locus: 17q21.33
Gene Diseases
The MKL1 WFIKKN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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