MKL1-TMEM218 Fusion FISH Probe
The MKL1-TMEM218 Fusion FISH Probe is used to confirm a fusion of the MKL1 and TMEM218 genes. The fusion of the MKL1 and TMEM218 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL1-TMEM218-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-RERE | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-REOR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-REGO | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-REGR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-OROR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GORE | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GROR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL1-TMEM218-20-AQAQ | 20 (40 μL) | 200 μL |
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MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
TMEM218 Gene Summary
The Transmembrane Protein 218 (TMEM218) gene is located on chr11 :124966398-124973205 at 11q24.2.
Gene Name: Transmembrane Protein 218
Chromosome: CHR11: 124966398 -124973205
Locus: 11q24.2
Gene Diseases
The MKL1 TMEM218 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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