MKL1-SERPIND1 Fusion FISH Probe
The MKL1-SERPIND1 Fusion FISH Probe is used to confirm a fusion of the MKL1 and SERPIND1 genes. The fusion of the MKL1 and SERPIND1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL1-SERPIND1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-RERE | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-REOR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-REGO | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-REGR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-OROR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GORE | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GROR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL1-SERPIND1-20-AQAQ | 20 (40 μL) | 200 μL |
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SERPIND1 Gene Summary
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
Gene Name: Serpin Family D Member 1
Chromosome: CHR22: 21128382 -21142008
Locus: 22q11.21
MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
Gene Diseases
The MKL1 SERPIND1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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