MKL1-CSNK1E Fusion FISH Probe
The MKL1-CSNK1E Fusion FISH Probe is used to confirm a fusion of the MKL1 and CSNK1E genes. The fusion of the MKL1 and CSNK1E genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL1-CSNK1E-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-RERE | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-REOR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-REGO | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-REGR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-OROR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GORE | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GROR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL1-CSNK1E-20-AQAQ | 20 (40 μL) | 200 μL |
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CSNK1E Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Name: Casein Kinase 1 Epsilon
Chromosome: CHR22: 38686696 -38714089
Locus: 22q13.1
MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
Gene Diseases
The MKL1 CSNK1E Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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