MKL1-ARAP1 Fusion FISH Probe
The MKL1-ARAP1 Fusion FISH Probe is used to confirm a fusion of the MKL1 and ARAP1 genes. The fusion of the MKL1 and ARAP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MKL1-ARAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MKL1-ARAP1-20-AQAQ | 20 (40 μL) | 200 μL |
|
MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
ARAP1 Gene Summary
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR11: 72396113 -72463434
Locus: 11q13.4
Gene Diseases
The MKL1 ARAP1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|