MKL1-APOL4 Fusion FISH Probe
The MKL1-APOL4 Fusion FISH Probe is used to confirm a fusion of the MKL1 and APOL4 genes. The fusion of the MKL1 and APOL4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MKL1-APOL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-RERE | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-REOR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-REGO | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-REGR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-REAQ | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-ORRE | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-OROR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-ORGO | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GORE | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GOOR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GOGO | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GOGR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GRRE | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GROR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GRGO | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GRGR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-AQRE | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-AQOR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-AQGO | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-AQGR | 20 (40 μL) | 200 μL |
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| MKL1-APOL4-20-AQAQ | 20 (40 μL) | 200 μL |
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MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
APOL4 Gene Summary
The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]
Gene Name: Apolipoprotein L4
Chromosome: CHR22: 36585175 -36600879
Locus: 22q12.3
Gene Diseases
The MKL1 APOL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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