MINK1-ALOX12 Fusion FISH Probe
The MINK1-ALOX12 Fusion FISH Probe is used to confirm a fusion of the MINK1 and ALOX12 genes. The fusion of the MINK1 and ALOX12 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MINK1-ALOX12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-RERE | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-REOR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-REGO | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-REGR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-REAQ | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-ORRE | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-OROR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-ORGO | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-ORAQ | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GORE | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GOOR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GOGO | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GOGR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GOAQ | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GRRE | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GROR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GRGO | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GRGR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-GRAQ | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-AQRE | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-AQOR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-AQGO | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-AQGR | 20 (40 μL) | 200 μL |
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| MINK1-ALOX12-20-AQAQ | 20 (40 μL) | 200 μL |
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ALOX12 Gene Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Arachidonate 12-lipoxygenase, 12S Type
Chromosome: CHR17: 6899383 -6914055
Locus: 17p13.1
MINK1 Gene Summary
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
Gene Name: Misshapen Like Kinase 1
Chromosome: CHR17: 4736634 -4801356
Locus: 17p13.2
Gene Diseases
The MINK1 ALOX12 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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