MIER1-LEPR Fusion FISH Probe
The MIER1-LEPR Fusion FISH Probe is used to confirm a fusion of the MIER1 and LEPR genes. The fusion of the MIER1 and LEPR genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MIER1-LEPR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-RERE | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-REOR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-REGO | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-REGR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-REAQ | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-ORRE | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-OROR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-ORGO | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GORE | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GOOR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GOGO | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GOGR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GRRE | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GROR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GRGO | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GRGR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-AQRE | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-AQOR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-AQGO | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-AQGR | 20 (40 μL) | 200 μL |
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| MIER1-LEPR-20-AQAQ | 20 (40 μL) | 200 μL |
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LEPR Gene Summary
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Gene Name: Leptin Receptor
Chromosome: CHR1: 65886334 -66103176
Locus: 1p31.3
MIER1 Gene Summary
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Gene Name: MIER1 Transcriptional Regulator
Chromosome: CHR1: 67390577 -67454302
Locus: 1p31.3
Gene Diseases
The MIER1 LEPR Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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