MID1-DOCK11 Fusion FISH Probe
The MID1-DOCK11 Fusion FISH Probe is used to confirm a fusion of the MID1 and DOCK11 genes. The fusion of the MID1 and DOCK11 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MID1-DOCK11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-RERE | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-REOR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-REGO | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-REGR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-REAQ | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-ORRE | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-OROR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-ORGO | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-ORAQ | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GORE | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GOOR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GOGO | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GOGR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GOAQ | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GRRE | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GROR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GRGO | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GRGR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-GRAQ | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-AQRE | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-AQOR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-AQGO | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-AQGR | 20 (40 μL) | 200 μL |
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| MID1-DOCK11-20-AQAQ | 20 (40 μL) | 200 μL |
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MID1 Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Gene Name: Midline 1
Chromosome: CHRX: 10413349 -10851809
Locus: Xp22.2
DOCK11 Gene Summary
The Dedicator Of Cytokinesis 11 (DOCK11) gene is located on chrX :117629871-117820123 at Xq24.
Gene Name: Dedicator Of Cytokinesis 11
Chromosome: CHRX: 117629871 -117820123
Locus: Xq24
Gene Diseases
The MID1 DOCK11 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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