MICA-NCR3 Fusion FISH Probe
The MICA-NCR3 Fusion FISH Probe is used to confirm a fusion of the MICA and NCR3 genes. The fusion of the MICA and NCR3 genes has been associated with Brain Lower Grade Glioma, and Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MICA-NCR3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-RERE | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-REOR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-REGO | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-REGR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-REAQ | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-ORRE | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-OROR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-ORGO | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GORE | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GOOR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GOGO | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GOGR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GRRE | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GROR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GRGO | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GRGR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-AQRE | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-AQOR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-AQGO | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-AQGR | 20 (40 μL) | 200 μL |
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| MICA-NCR3-20-AQAQ | 20 (40 μL) | 200 μL |
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NCR3 Gene Summary
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Name: Natural Cytotoxicity Triggering Receptor 3
Chromosome: CHR6_cox_hap2: 3066271 -3070374
Locus: 6p21.33
MICA Gene Summary
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: MHC Class I Polypeptide-related Sequence A
Chromosome: CHR6_qbl_hap6: 2661006 -2676580
Locus: 6p21.33
Gene Diseases
The MICA NCR3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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