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MGAT5-MBD5 Fusion FISH Probe

The MGAT5-MBD5 Fusion FISH Probe is used to confirm a fusion of the MGAT5 and MBD5 genes. The fusion of the MGAT5 and MBD5 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MGAT5-MBD5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MGAT5-MBD5-20-RERE 20 (40 μL) 200 μL
MGAT5-MBD5-20-REOR 20 (40 μL) 200 μL
MGAT5-MBD5-20-REGO 20 (40 μL) 200 μL
MGAT5-MBD5-20-REGR 20 (40 μL) 200 μL
MGAT5-MBD5-20-REAQ 20 (40 μL) 200 μL
MGAT5-MBD5-20-ORRE 20 (40 μL) 200 μL
MGAT5-MBD5-20-OROR 20 (40 μL) 200 μL
MGAT5-MBD5-20-ORGO 20 (40 μL) 200 μL
MGAT5-MBD5-20-ORAQ 20 (40 μL) 200 μL
MGAT5-MBD5-20-GORE 20 (40 μL) 200 μL
MGAT5-MBD5-20-GOOR 20 (40 μL) 200 μL
MGAT5-MBD5-20-GOGO 20 (40 μL) 200 μL
MGAT5-MBD5-20-GOGR 20 (40 μL) 200 μL
MGAT5-MBD5-20-GOAQ 20 (40 μL) 200 μL
MGAT5-MBD5-20-GRRE 20 (40 μL) 200 μL
MGAT5-MBD5-20-GROR 20 (40 μL) 200 μL
MGAT5-MBD5-20-GRGO 20 (40 μL) 200 μL
MGAT5-MBD5-20-GRGR 20 (40 μL) 200 μL
MGAT5-MBD5-20-GRAQ 20 (40 μL) 200 μL
MGAT5-MBD5-20-AQRE 20 (40 μL) 200 μL
MGAT5-MBD5-20-AQOR 20 (40 μL) 200 μL
MGAT5-MBD5-20-AQGO 20 (40 μL) 200 μL
MGAT5-MBD5-20-AQGR 20 (40 μL) 200 μL
MGAT5-MBD5-20-AQAQ 20 (40 μL) 200 μL

MGAT5 Gene Summary

The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

Gene Name: Mannosyl (alpha-1,6-)-glycoprotein Beta-1,6-N-acetyl-glucosaminyltransferase

Chromosome: CHR2: 135011829 -135206468

Locus: 2q21.2-q21.3

MBD5 Gene Summary

This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Jul 2017]

Gene Name: Methyl-CpG Binding Domain Protein 5

Chromosome: CHR2: 148778579 -149271044

Locus: 2q23.1

Gene Diseases

The MGAT5 MBD5 Fusion has been associated with the following diseases:

Disease Name
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.